Nexgard vs Simparica Trio

Fleas and ticks are among the problems that worry pet parents the most as they can infect their furry partner all year round. Now, this makes it crucial to ensure that they are thoroughly protected.

There are several products available that work effectively in terms of providing effective parasitic protection. But which of those several products are better? Well, we have shortlisted a couple of them for you, Nexgard and Simparica Trio. These are two of the most talked about parasite protection treatments for dogs.

While both of these treatments work more or less in a similar manner, there are fundamental differences in terms of composition, effect and other aspects. This blog gives you a detailed comparison of these two brands and helps you make a better choice for your furry baby.

So, let’s get started!

About Nexgard & Simparica Trio


Trusted and recommended by vets, Nexgard is a palatable beef-flavored chewable parasite treatment for dogs. With afoxolaner as the active ingredients, this formula provides long-lasting protection against fleas and ticks infestation.

Nexgard works against ticks and fleas, providing prompt relief and provides effective protection against Lyme disease. It is suitable for puppies and dogs from 8 weeks of age with at least 4 lbs of body weight.

Simparica Trio

On the other hand, Simparica Trio is a chewable formula, offering multi-spectrum parasitic coverage against both external and internal parasites. It protects dogs against fleas, ticks, roundworms, and hookworms, and prevents heartworm disease and Lyme disease.

Simparica Trio contains a trio of ingredients including sarolaner, moxidectin and pyrantel. It is recommended for puppies and dogs from 8 weeks of age, weighing at least 2.8 lbs.

Nexgard vs. Simparica Trio

Let’s understand these products better and learn about the difference with the following table.

Nexgard vs Simparica Trio

End Remarks: Which One is Better?

Both Nexgard and Simparica Trio are very similar in their mode of action and the range of parasites they cover. However, as the above comparison table highlights, there are some fundamental differences. Regardless of these differences, both these products are highly effective. So, it’s best to consult your vet to select the most suitable treatment for your dog.

Frequently Asked Questions About Nexgard&Simparica Trio

Q: Is Nexgard/Simparica Trio safe for my dog?

A: Yes, both these treatments are recommended by vets worldwide. Either of them are safe for dogs and puppies from 8 weeks, weighing at least 4 lbs(Nexgard) and 2.8 lbs (Simparica Trio). However, it’s best to consult with your vet before moving forward with either of these treatments.

Q: How long does it take for Nexgard/Simparica Trio to work?

A: Nexgard takes 8 hours to kill fleas and ticks within 48 hours of administration. Simparica Trio begins killing fleas within 3 hours.

Q: Can I give my dog Nexgard/Simparica Trio on an empty stomach?

A: Nexgard/Simparica Trio can be given to dogs with or without food. 

Q: How long does the result of Nexgard/Simparica Trio last?

A: A single dose of Nexgard and Simparica Trio lasts for 35 days and one month, respectively.

Q: What if I miss a dose of Nexgard/Simparica Trio?

A: If you miss a dose, immediately administer a dose of Nexgard/Simparica Trio chew and resume the monthly schedule.

Q: What if my dog shows a bad reaction after administering Nexgard/Simparica Trio?

A: If your dog shows any adverse reaction or unusual behavior, contact your vet immediately and discuss the symptoms.