Revolution Plus vs. NexGard Combo – Which One to Choose?

Bringing up a cat is a magical experience. These cute furballs come into our homes and fill our lives with immense happiness. However, parenting a cat isn’t always hunky-dory and requires consistent effort to maintain their well-being and keep them protected from internal and external parasites. Thankfully, we have access to a wide range of treatments that work effectively to keep parasites at bay. In this blog, we will compare two popular parasitic treatments for cats, Revolution Plus and NexGard Combo. We will also draw a detailed comparison between them to help you choose an appropriate product for your feline baby.
Read on to find out more!
Revolution Plus vs. NexGard Combo – A Quick Glance
Revolution Plus
Available as a ready-to-use topical solution, Revolution Plus for Cats is designed to prevent heartworm disease caused by Dirofilaria immitis. It also treats and controls intestinal worms like roundworms and hookworms. The treatment further treats and controls ear mite infestations. Additionally, it kills adult fleas and helps in the treatment and prevention of flea infestations. The formula also helps in the prevention of tapeworm infections by directly killing fleas. It further treats and controls tick infestations caused by lone star ticks, Gulf coast ticks, American dog ticks, and black-legged ticks. The treatment offers protection for one month and is suitable for cats and kittens from 8 weeks of age, weighing at least 2.8 lbs.
NexGard Combo
NexGard Combo for Cats comes in the form of a topical formula, indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It also treats and controls roundworm, hookworm, and tapeworm infections. The treatment further kills adult fleas and treats and controls flea infestations. Additionally, it treats and controls tick infestations caused by black-legged ticks and lone star ticks. The product is designed for monthly administration and caters to cats and kittens from 8 weeks of age, weighing at least 1.8 lbs.
Similarities & Differences
Let’s look at the similarities and differences between Revolution Plus and NexGard Combo.
The Similarities
- Both products come in the form of a ready-to-use topical formula.
- Both helps prevent heartworm disease caused by Dirofilaria immitis.
- NexGard Combo treats tapeworm directly while Revolution Plus prevents tapeworm infection indirectly by killing fleas
- Both kill adult fleas and treat and prevent flea infestations.
- Both treatments treat and control tick infestations caused by lone star ticks and black-legged ticks.
- Both remain effective for one month.
- Both products are designed for cats and kittens from 8 weeks of age.
- The safe use of both treatments has not been established in breeding, pregnant, and lactating queens.
The Differences
- Revolution Plus treats and controls ear mite infections. NexGard Combo has no such claim.
- While Revolution Plus treats and controls tick infestations caused by Gulf Coast ticks and American dog ticks, NexGard Combo doesn’t.
- Revolution Plus is suitable for cats and kittens weighing at least 2.8 lbs. However, NexGard Combo is designed for cats and kittens weighing at least 1.8 lbs.
- While Revolution Plus is composed of selamectin and sarolaner as its active ingredients, NexGard Combo features esafoxolaner, eprinomectin, and praziquantel.
Revolution Plus vs. NexGard Combo – A Detailed Analysis
The following table features a detailed comparison between the key features of Revolution Plus and NexGard Combo.
Frequently Asked Questions
1. Are Revolution Plus and NexGard Combo safe for breeding, pregnant, and lactating cats?
The safe use of both has not been evaluated in breeding, pregnant, or lactating cats.
2. Do Revolution Plus and NexGard Combo cover heartworms?
Both are effective in the prevention of heartworm disease.
3. Are there any potential side effects of Revolution Plus and NexGard Combo?
Both are generally well tolerated by cats of all breeds when used according to the instructions mentioned on the product label.
4. Can Revolution Plus and NexGard Combo be used together?
Generally, they should not be used together as combining them without veterinary direction could increase the risk of adverse effects.
5. Which is more suitable for indoor cats? Revolution Plus or NexGard Combo?
Many veterinarians consider Revolution Plus sufficient for most indoor cats because it covers fleas, heartworm, common intestinal worms, ear mites, and ticks. However, if a cat hunts prey or has a history of tapeworms, NexGard Combo may offer an advantage.
Ending Note
Revolution Plus and NexGard Combo are vet-recommended topical formulas designed to offer flea and tick control for cats and protect against multiple species of other parasites. However, the treatments differ in parasite coverage, composition, and weight criteria.
Both are available on PetCareSupplies at great discounts. Check out our online store to get your hands on them from the comfort of your home.


